Endocrine Abstracts

A prerequisite milieu for normal growth is an intact hormonal system, adequate nutrition and normal physical activity. Any arm of this triangle, if interrupted, may change the normal growth pattern. Timing and interval range of disruption of this homeostasis, may affect the outcome up to irreversible results. The 3 polynomial growth model of Karlberg helps to detect, past irreversible growth retardation and in foresee and prevent growth deteriorationA no...

Objective: Growth hormone (GH) replacement therapy currently requires daily injections. This may cause poor compliance, inconvenience and distress for patients. CTP-modified hGH (MOD-4023) has been developed for once-weekly administration in growth hormone deficient (GHD) adults and children. The 18 and 24 month efficacy of once-weekly subcutaneous (SC) administration of MOD-4023 was evaluated in a Phase 2 study in children with GH deficiency.Design and ...

Objective: Growth hormone (GH) replacement therapy currently requires daily injections. This may cause poor compliance, inconvenience and distress for patients. CTP-modified human GH (MOD-4023) has been developed for once-weekly administration in growth hormone-deficient (GHD) adults and children. In the present Phase 2 study, the safety and tolerability of once-weekly subcutaneous (SC) administration of MOD-4023 were evaluated in GHD children.Design and...